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KMID : 0363420210350010030
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Journal of Korean Oriental Pediatrics
2021 Volume.35 No. 1 p.30 ~ p.39
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The Anti-Inflammatory Effect of Duchi extract on Ulcerative Colitis
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Yang Byeng-Mok
Ahn Sang-Hyun
Kim Ki-Bong
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Abstract
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Objective: The purpose of this study is to learn the anti-inflammatory effect of Douchi on ulcerative colitis (UC).
Methods: Three-month-old mice were divided into 4 groups as follows: control group (Ctrl), UC induced group (UCEG), Pentasa treated group after inducing UC (OPTG), and Douchi treated group after inducing UC (FGTG). NF-κB, p-IκB, iNOS, COX-2 were observed by immunohistochemistry and Masson trichrome, PAS, and Phloxine-tartrazine staining were used to observe histochemical changes.
Results: Inflammation indicators of the large intestine were significantly lower in FGTG than in the UCEG and OPTG. Also, indicators involved in pulmonary alveolar formation were significantly higher in the FGTG than in the UCEG and OPTG.
Conclusions: The result of this study suggests that Douchi extract was effective in ulcerative colitis and helped in the formation of alveolar. This result suggests that the lungs and colon are correlated.
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KEYWORD
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Douchi, Ulcerative colitis, Inflammation, Large intestine
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